If you have found that the evidence is valid, significant, and generalizable to your patient, you must decide whether and how to apply the findings to your patient's care. We must consider how the population, intervention/treatments can be generalized to your specific patient.
This step is arguably the most challenging because you must combine the evidence and your clinical knowledge with the patients' values and considerations. It is within this step that you are making the clinical decision.
Prior to applying your clinical decision, ask yourself the following questions: